NPR Music's Tiny Desk concert series recently featured the legendary Isley Brothers in a special home performance. Lead singer Ronald Isley shared anecdotes about the band's iconic song "That Lady", recounting encounters with Jimi Hendrix and Kendrick Lamar that demonstrate their lasting legacy. The Isley Brothers, originally from Cincinnati, Ohio, have had a career spanning over seven decades, with hits like "Shout" in the late 1950s propelling them to fame. Their lineup changes over the years, including the addition of younger brothers and brothers-in-law, led to continued success with albums like 3 + 3 and Eternal. Despite various lineup changes, brothers Ronald and Ernie Isley have maintained the band's presence, selling over 18 million units in the U.S. alone and charting hits across six decades. The Isley Brothers have been honored by prestigious institutions like the Rock and Roll Hall of Fame and received the Grammy Lifetime Achievement Award in 2014.