The Tiny Desk concert featured the cast, band, and composer of the musical Kimberly Akimbo, including Broadway star Victoria Clark portraying the title character. The musical tells the poignant coming-of-age story of a 16-year-old girl with a rare genetic disease that causes her to age rapidly, blending humor, sadness, and inspiration. Songs in the show are performed by various characters in Kimberly's life, from family members to friends.

The Off-Broadway premiere of Kimberly Akimbo in 2021 at the Linda Gross Theater garnered critical acclaim for its performances, book, and score, with subsequent awards at the Drama Desk, Lucille Lortel, and Outer Critics Circle Awards. The production then transitioned to Broadway, opening at the Booth Theatre in 2022 and receiving accolades, including five Tony Awards.

The concert showcased the talents behind the musical, offering a glimpse into the heartfelt and engaging narrative brought to life by the cast and creative team. With its unique storyline and memorable performances, Kimberly Akimbo continues to resonate with audiences for its touching exploration of family, secrets, and the pursuit of happiness despite life's challenges.